Multivariate MArginal ePIstasis Test (mvMAPIT)
In my work as PhD student I developed the multivariate MArginal ePIstasis Test (mvMAPIT) – a multi-outcome generalization of a recently proposed epistatic detection method which seeks to detect marginal epistasis or the combined pairwise interaction effects between a given variant and all other variants. By searching for marginal epistatic effects, one can identify genetic variants that are involved in epistasis without the need to identify the exact partners with which the variants interact – thus, potentially alleviating much of the statistical and computational burden associated with conventional explicit search based methods. Find the documentation of the R package I developed and maintain here.
The R implementation for this method is now available on CRAN.